نوشته اصلی از سوی Russell
به نظر میرسه کاهش کالری تا حدی میتونه برای انسان مفید باشه ، اما هنوز نتایج قطعی گرفته نشده :
Calorie restriction - WiKi
Caloric restriction (CR), or calorie restriction, is a dietary regimen that is based on low calorie intake. "Low" can be defined relative to the subject's previous intake before intentionally restricting calories, or relative to an average person of similar body type. Caloric restriction without malnutrition has been shown to work in a variety of species, among them yeast, fish, rodents and dogs to decelerate the biological aging process, resulting in longer maintenance of youthful health and an increase in both median and maximum lifespan.[1]
The long-term effects of moderate CR with adequate intake of nutrients on humans are unknown.[2]
Two main lifespan studies have been performed involving nonhuman primates (rhesus monkeys). One, begun in 1987 by the National Institute on Aging, published interim results in August 2012 indicating that CR confers health benefits in these animals, but did not demonstrate increased median lifespan.[3] A second study by the University of Wisconsin beginning in 1989 issued preliminary lifespan results in 2009,[1][4][5] and final results in 2014.[6] It found that CR primates were only 36.4% as likely to die from age-related causes when compared with control animals, and had only 56.2% the rate of death from any cause.
از لحاظ فرگشتیک هم اشاره شده به موضوع :
Evolutionمثلا ژاپنی ها یک رژیم غذایی قدیمی دارن که گفته میشه باعث طول عمر زیاد میشه :
It has been recently argued that during years of famine, it may be evolutionarily desirable for an organism to avoid reproduction and to up-regulate protective and repair enzyme mechanisms to try to ensure that it is fit for reproduction in future years. This argument seems to be supported by recent work studying hormones.[30] A study on male mice found that CR generally feminizes gene expression, and that many of the most significantly changed individual genes are involved in aging, hormone signaling, and p53-associated regulation of the cell cycle and apoptosis; it concluded that the life-extending effects of CR may arise partly from a shift toward a gene expression profile more typical of females.[31] Prolonged severe CR lowers total serum and free testosterone while increasing SHBG concentrations in humans; these effects are independent of adiposity.[32]
See also: Insulin § Physiological effects
Lowering of the concentration of insulin and substances related to insulin, such as insulin-like growth factor 1 and growth hormone, has been shown to up-regulate autophagy, the repair mechanism of the cell.[33] A related hypothesis suggests that CR works by decreasing insulin levels and thereby up-regulating autophagy,[33][34] but CR affects many other health indicators, and it is still undecided whether insulin is the main concern.[35] Calorie restriction has been shown to increase DHEA in primates, but it has not been shown to increase DHEA in post-pubescent primates.[36][37] The extent to which these findings apply to humans is still under investigation.
Okinawa diet - WiKi
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